Guilty Gear Isuka in an ambitious spin-off, trying out some unique game modes and mechanics, without straying too far away from the orthodox Guilty Gear combat recipe. There are also quite a few unique characters introduced for the first (and last time), like the awakened versions of Sol & Ky, Kakusei Sol & Kakusei Ky.
You can also unlock the Arcade Mode's boss Leopaldon, as well as Zako A, B and C, from the Zako-Dan organization. Isuka also features a unique 2v2 fighting system, where 4 characters fight at once, in two separate lanes.